Which medication is associated with prolongation of the QT interval on an ECG?

The correct answer highlights that citalopram, sertraline, and escitalopram are all associated with the potential for QT interval prolongation on an electrocardiogram (ECG). QT interval prolongation is a concern because it can lead to serious heart rhythm abnormalities, such as Torsades de Pointes, which can be life-threatening.

Citalopram, in particular, has been noted in studies to cause significant QT prolongation, especially at higher doses. Dosing considerations and monitoring are recommended to mitigate this risk. Sertraline and escitalopram also carry a risk for QT interval prolongation but to a lesser extent compared to citalopram. Despite the differences in their associations, the fact remains that all three medications have been reported to have some risk for this cardiological side effect.

Understanding these risks is essential for healthcare providers, particularly when prescribing these medications to patients with known cardiac conditions or those who are taking other medications that might further prolong the QT interval.