What is considered a common first-line drug for treating depression with minimal side effects?

Sertraline (Zoloft) is recognized as a common first-line treatment for depression due to its favorable side effect profile compared to other antidepressants. It belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs), which are widely used for their effectiveness and generally milder side effects, such as gastrointestinal disturbances or mild insomnia.

SSRIs like sertraline are preferred in clinical practice because they tend to have a lower incidence of severe adverse effects, such as sedation or anticholinergic effects, which can be seen with older antidepressants. Additionally, sertraline is effective for a range of depressive and anxiety disorders, making it a versatile option for treatment.

In contrast, other medications listed may have more significant side effects or may not be considered first-line treatments. Amitriptyline is a tricyclic antidepressant that can cause sedation, weight gain, and other side effects that limit its suitability as a first-line agent. Phenelzine is a monoamine oxidase inhibitor (MAOI) requiring dietary restrictions to avoid serious side effects, making it less practical as an initial treatment. Trazodone, while often used for depression and sleep, may not be the first choice for depression due to its